RESEARCH

From Drug Delivery to 3D Biomimetics

We integrate nanoparticle and hydrogel formulations, post-surgical local therapy, 3D biomimetics, cancer stem-cell targeting, and pharmacokinetics/pharmacodynamics.

Researcher conducting a hydrogel formulation experiment
Nanoparticle research diagram
01

NANOPARTICLE FORMULATION

Nanoparticles

We design delivery systems for poorly soluble and combination drugs using polymeric micelles, albumin nanoparticles, and other nanoformulations.

We evaluate solubilization, stability, encapsulation efficiency, and release behavior, and develop nanoparticle formulations for combination anticancer therapy.

  • Polymeric micelles
  • Albumin nanoparticles
  • Combination delivery
Hydrogel research diagram
02

HYDROGEL FORMULATION

Hydrogels

We design injectable local drug-delivery formulations and sequential-release systems based on thermosensitive polymeric hydrogels.

We control sol-gel transition and drug release, then evaluate the anticancer effects of nanoparticle-hydrogel composite formulations.

  • Thermosensitive hydrogels
  • Local delivery
  • Sequential release
Diagram of post-surgical local formulation research
03

POST-SURGICAL LOCAL FORMULATION

Post-Surgical Local Formulations

We design surgical-site formulations that target residual cancer cells and local recurrence after tumor resection.

Using sprayable and injectable hydrogels with nanoparticle composites, we control local drug retention and release and evaluate therapeutic efficacy and recurrence prevention.

  • Post-resection formulation
  • Local drug delivery
  • Local recurrence prevention
Diagram of 3D biomimetic research
04

3D BIOMIMETICS

3D Biomimetics

We use tumoroids and microfluidic platforms to recreate the tumor microenvironment and time-dependent drug delivery.

Three-dimensional tumor models and flow systems reproduce changing drug concentrations and size-dependent nanoparticle delivery.

  • Tumoroids
  • Microfluidics
  • In vitro biomimetic models
Cancer stem-cell targeting research diagram
05

CANCER STEM CELL TARGETING

Cancer Stem-Cell Targeting

We design immunoliposomes and targeted nanocarriers that recognize surface markers on cancer stem cells.

We evaluate selectivity and therapeutic efficiency through CD133, hyaluronan, and angiopep-2 targeting and the combined delivery of anticancer and gene therapies.

  • CD133
  • Immunoliposomes
  • Targeted delivery
Pharmacokinetics and pharmacodynamics research diagram
06

PHARMACOKINETICS & PHARMACODYNAMICS

Pharmacokinetics & Pharmacodynamics

We quantitatively analyze relationships among systemic exposure, tissue distribution, excretion, and efficacy of drugs and nanoformulations.

We compare the pharmacokinetics of intravenous, oral, inhaled, and local formulations and connect biodistribution and tumor-inhibition results to formulation design.

  • Pharmacokinetics
  • Biodistribution
  • PK/PD

CONNECTED WORKFLOW

01

FORMULATE

Design and evaluate nanoparticle formulations.

02

ENGINEER

Engineer hydrogel properties and release.

03

MODEL

Model biological environments with 3D and microfluidic platforms.